Family-based genome-wide association studies (GWAS) can separate direct from indirect genetic effects such as genetic nurture, population stratification, and assortative mating, yet these designs often suffer from limited statistical power because …
The Perturbation Discrimination Score (PDS) is increasingly used to evaluate whether predicted perturbation effects remain distinguishable, including in Systema and the Virtual Cell Challenge. However, its behavior in high-dimensional gene-expression …
Heavy-tailed combination tests, such as the Cauchy combination test and harmonic mean p-value method, are widely used for testing global null hypotheses by aggregating dependent p-values. However, their theoretical guarantees under general dependence …
Two-sample Mendelian randomization (MR) is widely applied to binary exposures and outcomes. Yet standard MR models rely on linear effect assumptions that are difficult to interpret for binary traits. Although liability-based interpretations have been …